Taxifolin, also known as dihydroquercetin, is a potent flavonoid primarily found in Siberian larch, but also found in other plants such as acai and milk thistle. It is known for its many health-promoting properties, including its ability to protect cell membranes, enhance microcirculation, and reduce inflammation. Discovered in the 1950s, taxifolin has been the subject of multiple scientific studies, particularly in Russia, where it is used in therapeutic and cosmetic . This article explores in depth the characteristics, laboratory analysis, and applications of this promising molecule.
1. What is Taxifolin?
1.1. Definition and general characteristics
Taxifolin (CAS: 480-18-2) is a flavonoid belonging to flavonols, a subgroup of flavonoids. Naturally present in certain trees such as Siberian larch (Larix sibirica), but also in acai and milk thistle, it is known for its beneficial effects on health, particularly for its ability to strengthen blood vessels and improve blood circulation. This flavonoid is also used as a natural antioxidant.
1.2. Origin and discovery
Taxifolin was first isolated by Russian scientists in the 1950s. This molecule quickly attracted interest for its antioxidant properties, which are far more powerful than most flavonoids. Derived primarily from the bark of the Siberian larch tree, taxifolin has proven beneficial in several areas of health.
2. Structure and molecular properties of Taxifolin
2.1. Molecular formula and chemical structure
The molecular formula of taxifolin is C15H12O7, and its molecular weight is 304.25 g/mol. It consists of two phenyl groups (A and B), linked by a heterocyclic ring (C). This complex structure allows it to play a major role in neutralizing free radicals and other reactive oxygen species.
2.2. Physicochemical properties
- Solubility : Taxifolin is soluble in hot water, ethanol and ethyl acetate.
- Appearance : It appears as a white to pale yellow crystalline powder.
- Stability : Taxifolin is stable at room temperature if stored under specific conditions, with a temperature below 4°C and controlled humidity. It can therefore be stored for several years without altering its properties.
3. Laboratory analysis and dosage of Taxifoline
3.1. Commonly used analysis methods
Taxifolin is analyzed in various matrices using chromatographic techniques such as high-performance liquid chromatography (HPLC) coupled with a UV detector (HPLC-UV). This method is commonly used to quantify flavonoid compounds, including taxifolin, in plant extracts or dietary supplements.
3.2. Examples of analytical tests
Taxifolin analysis can be performed on matrices such as larch dry extract. The HPLC-UV method allows the detection and quantification of this molecule with a limit of quantification (LOQ) of 10 ppm. This type of analysis guarantees maximum precision in laboratory assays.
4. Antioxidant and anti-inflammatory properties of Taxifolin
4.1. A powerful antioxidant
Studies show that taxifolin has far more powerful antioxidant properties than most flavonoids. It is able to effectively neutralize free radicals such as superoxides and peroxides, thus reducing cellular damage caused by oxidative stress. By strengthening cell membranes, taxifolin protects the body against the harmful effects of premature cellular aging.
4.2. The anti-inflammatory effect
Taxifolin also exerts a strong anti-inflammatory action. It inhibits the production of certain enzymes responsible for inflammatory processes in the body. This helps reduce chronic inflammation, which is particularly beneficial in the prevention of inflammation-related diseases, such as cardiovascular disease or metabolic disorders.
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5. Beneficial effects on cardiovascular health
5.1. Improvement of microcirculation and reduction of blood viscosity
Taxifolin significantly improves blood microcirculation in the capillaries. By reducing blood viscosity, it helps prevent clot formation and improves tissue oxygenation. This reduces the risk of cardiovascular events, such as heart attacks or strokes.
5.2. Reduction of cholesterol levels
Studies have shown that taxifolin helps lower blood cholesterol levels, particularly LDL (low-density lipoprotein), while increasing HDL (high-density lipoprotein). By reducing lipid oxidation in cell membranes, it prevents atherosclerosis, a leading cause of cardiovascular disease.
6. Taxifolin and neurological protection
6.1. Protection against oxidative stress in the brain
Because the brain is particularly vulnerable to oxidative stress, taxifolin plays a key role in protecting nerve cells from free radical damage. In particular, it protects white blood cells from adhering to blood vessel walls in vulnerable areas of the brain, providing essential neuroprotection against oxidative damage.
6.2. Prevention of strokes
By improving blood circulation and reducing blood viscosity, taxifolin significantly reduces the risk of strokes. Clinical studies have shown that patients taking taxifolin had a faster recovery rate after a stroke, with a reduction in associated neurological symptoms.
7. Applications of Taxifolin in industry
7.1. Use in cosmetics
Taxifolin is used in cosmetic due to its anti-aging properties. By protecting the skin from oxidative stress, it helps slow the aging process and maintain firm, elastic skin. It is also included in products to protect the skin from external aggressions such as UV rays and pollution.
7.2. Food additive and nutritional supplement
In Russia and the United States, taxifolin is commonly used in dietary supplements due to its antioxidant and cardioprotective properties. It is often added to nutrition bars, energy drinks, and supplements to improve overall health, particularly in people with cardiovascular risks or impaired metabolism.
8. Limitations and precautions for use
8.1. Potential risk factors
Despite its many benefits, it is important to take certain precautions when consuming taxifolin. People with liver problems or taking blood thinners should consult a healthcare professional before using supplements containing this flavonoid.
8.2. Recommendations on consumption
The recommended dose varies depending on the study, but it is generally recommended not to exceed 40 to 80 mg per day to avoid any risk of drug interactions or adverse effects. Moderate consumption is therefore recommended, especially for people taking medications to treat metabolic or cardiovascular disorders.
Conclusion
Taxifolin stands out as a flavonoid with multiple virtues, mainly due to its antioxidant and anti-inflammatory properties
