Taxifolin, also known as dihydroquercetin, is a potent flavonoid found primarily in Siberian larch, but also present in other plants such as acai and milk thistle. It is recognized for its numerous health benefits, including its ability to protect cell membranes, enhance microcirculation, and reduce inflammation. Discovered in the 1950s, taxifolin has been the subject of extensive scientific research, particularly in Russia, where it is used in therapeutic and cosmetic . This article explores in depth the characteristics, laboratory analysis, and applications of this promising molecule.
1. What is Taxifoline?
1.1. Definition and general characteristics
Taxifolin (CAS: 480-18-2) is a flavonoid belonging to the flavonols, a subgroup of flavonoids. Naturally present in certain trees such as Siberian larch (Larix sibirica), as well as in acai and milk thistle, it is known for its beneficial health effects, particularly its ability to strengthen blood vessels and improve blood circulation. This flavonoid is also used as a natural antioxidant.
1.2. Origin and discovery
It was in the 1950s that Russian scientists first isolated taxifolin. This molecule quickly attracted interest due to its antioxidant properties, which are far more potent than those of most flavonoids. Primarily derived from the bark of the Siberian larch, taxifolin has proven beneficial in several areas of health.
2. Structure and molecular properties of Taxifolin
2.1. Molecular formula and chemical structure
The molecular formula of taxifolin is C15H12O7, and its molecular weight is 304.25 g/mol. It consists of two phenyl groups (A and B) linked by a heterocyclic ring (C). This complex structure allows it to play a major role in neutralizing free radicals and other reactive oxygen species.
2.2. Physico-chemical properties
- Solubility : Taxifolin is soluble in hot water, ethanol, and ethyl acetate.
- Appearance : It appears as a crystalline powder, white to pale yellow in color.
- Stability : Taxifolin is stable at room temperature if stored under specific conditions, with a temperature below 4°C and controlled humidity. It can therefore be stored for several years without any alteration of its properties.
3. Laboratory analysis and dosage of Taxifoline
3.1. Commonly used analytical methods
Taxifolin is analyzed in various matrices using chromatographic techniques such as high-performance liquid chromatography (HPLC) coupled with a UV detector (HPLC-UV). This method is commonly used to quantify flavonoid compounds, including taxifolin, in plant extracts or dietary supplements.
3.2. Examples of analytical tests
Taxifolin analysis can be performed on matrices such as larch dry extract. The HPLC-UV method allows for the detection and quantification of this molecule with a limit of quantification (LOQ) of 10 ppm. This type of analysis guarantees maximum precision in laboratory assays.
4. Antioxidant and anti-inflammatory properties of Taxifolin
4.1. A powerful antioxidant
Studies show that taxifolin possesses far more potent antioxidant properties than most flavonoids. It is capable of effectively neutralizing free radicals such as superoxides and peroxides, thus reducing cellular damage caused by oxidative stress. By strengthening cell membranes, taxifolin protects the body against the harmful effects of premature cell aging.
4.2. The anti-inflammatory effect
Taxifolin also has a strong anti-inflammatory effect. It inhibits the production of certain enzymes responsible for inflammatory processes in the body. This helps reduce chronic inflammation, which is particularly beneficial in preventing inflammation-related diseases, such as cardiovascular disease or metabolic disorders.
Are you looking for an analysis?
5. Beneficial effects on cardiovascular health
5.1. Improvement of microcirculation and reduction of blood viscosity
Taxifolin significantly improves blood microcirculation at the capillary level. By decreasing blood viscosity, it helps prevent clot formation and improves tissue oxygenation. This reduces the risk of cardiovascular events, such as heart attacks or strokes.
5.2. Reduction of cholesterol levels
Studies have shown that taxifolin helps lower blood cholesterol levels, particularly LDL (low-density lipoprotein), while increasing HDL (high-density lipoprotein). By reducing lipid oxidation in cell membranes, it helps prevent atherosclerosis, a major cause of cardiovascular disease.
6. Taxifolin and neurological protection
6.1. Protection against oxidative stress in the brain
Because the brain is particularly vulnerable to oxidative stress, taxifolin plays a key role in protecting nerve cells from damage caused by free radicals. Specifically, it protects white blood cells from adhering to the walls of blood vessels in vulnerable areas of the brain, thus providing essential neuroprotection against oxidative damage.
6.2. Prevention of cerebrovascular accidents
By improving blood circulation and reducing blood viscosity, taxifolin significantly reduces the risk of stroke. Clinical studies have shown that patients taking taxifolin have a faster recovery rate after a stroke, with a reduction in associated neurological symptoms.
7. Applications of Taxifolin in Industry
7.1. Use in cosmetics
Taxifolin is used in cosmetic due to its anti-aging properties. By protecting the skin against oxidative stress, it helps slow the skin aging process and maintain firm, elastic skin. It is also included in products to protect the skin against external aggressors such as UV rays and pollution.
7.2. Food additives and nutritional supplements
In Russia and the United States, taxifolin is commonly used in dietary supplements due to its antioxidant and cardioprotective properties. It is often added to nutrition bars, energy drinks, and supplements to improve overall health, particularly in people with cardiovascular risks or impaired metabolism.
8. Limitations and precautions for use
8.1. Potential risk factors
Despite its numerous benefits, it is important to take certain precautions when consuming taxifolin. Individuals with liver disorders or those taking anticoagulants are advised to consult a healthcare professional before using supplements containing this flavonoid.
8.2. Consumption Recommendations
The recommended dose varies depending on the study, but it is generally advised not to exceed 40 to 80 mg per day to avoid any risk of drug interactions or adverse effects. Moderate consumption is therefore recommended, especially for people taking medication to treat metabolic or cardiovascular disorders.
Conclusion
Taxifolin stands out as a flavonoid with multiple benefits, primarily due to its antioxidant and anti-inflammatory properties
